Limitations of iron-based stem cell tracking in MRI-monitoring of stem cell therapies in vivo
نویسندگان
چکیده
Introduction. Treatment of neurodegenerative diseases such as stroke continues to be an elusive goal for the medical community. While stem cells hold great promise for neuroregeneration, their migration and mechanism of repair are yet to be clearly defined. Literature suggests that mesenchymal stem cells (MSC) can be influenced to differentiate into neural cells in-vitro [1]. Several strategies have been developed for understanding their regenerative mechanism; this investigation makes use of micron-sized superparamagnetic iron-oxide (MPIO) particles for tracking MSCs in MRI. We outline some of the issues surrounding this method of stem cell tracking.
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